Mati J K, Horrobin D F, Bramley P S
Br Med J. 1973 Apr 21;2(5859):149-51. doi: 10.1136/bmj.2.5859.149.
In sheep the administration of single intramuscular injections of dexamethasone into the fetus was shown to be an effective method of initiating parturition. In a controlled trial in women who had gone beyond the 41st week of pregnancy 20 mg betamethasone in saline (six patients) or saline alone (five patients) was injected into the amniotic fluid. In the betamethasone-treated group delivery occurred 78.9 +/- 10.2 (S.D.) hours after injection while in the control group it occurred 323 +/- 62 (S.D.) hours after injection (P < 0.01). In one woman with an anencephalic pregnancy intra-amniotic injection failed to initiate parturition but delivery occurred 88.5 hours after intramuscular injection of betamethasone into the fetus.
在绵羊中，向胎儿单次肌内注射地塞米松被证明是启动分娩的有效方法。在一项针对怀孕超过41周的女性的对照试验中，将20毫克倍他米松溶于生理盐水（6例患者）或仅注射生理盐水（5例患者）注入羊膜腔。在倍他米松治疗组中，注射后78.9±10.2（标准差）小时分娩，而在对照组中，注射后323±62（标准差）小时分娩（P<0.01）。在一名无脑儿妊娠的女性中，羊膜腔内注射未能启动分娩，但在向胎儿肌内注射倍他米松88.5小时后分娩。
