Toga A W, Burton H A
J Neurosci Res. 1979;4(3):215-24. doi: 10.1002/jnr.490040309.
Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was demonstrated in sham operated animals. Rats in which the lateral septum was damaged demonstrated a paradoxically smaller learning deficit in the presence of a conditioned stimulus that was previously presented without reinforcement, when compared to the performance of both septal lesioned rats no receiving nonreinforced preexposure and sham operates receiving preexposure. The interaction of nonreinforced preexposure and lateral septal lesions can be explained using a proposed sensitization hypothesis.
大鼠中隔外侧核受损会导致对先前无意义刺激出现非典型学习。对刺激进行无强化的预暴露通常会使随后利用该刺激进行学习变得更加困难。这种预暴露对学习的影响被称为潜伏抑制，在假手术动物中得到了证实。与未接受无强化预暴露的中隔损伤大鼠和接受预暴露的假手术大鼠的表现相比，中隔外侧核受损的大鼠在面对先前无强化呈现的条件刺激时，表现出反常地较小的学习缺陷。无强化预暴露与中隔外侧核损伤之间的相互作用可以用提出的敏化假说来解释。
