Weiss K R, Friedman R, McGregor S
Acta Neurobiol Exp (Wars). 1974;34(4):491-504.
In Experiment I, the latent inhibition effect; i.e., retardation of conditioned response acquisition when a previously presented but not reinforced stimulus is subsequently used as the conditioned stimulus, was investigated in normal and septal-lesioned rats. Normal animals subjected to 30 nonreinforced CS presentations prior to CS-shock pairings, were retarded in active avoidance acquisition compared to normal animals given no nonreinforced CS presentations. The same manipulation failed to produce such a difference in septal-lesioned rats. In Experiment II, while drinking, thirsty normal and septal-lesioned rats were exposed to the same stimulus which served as CS in Experiment I. The course of suppression of on-going drinking was used as a measure of orienting response habituation. Since no differences in habituation were found between normal and septal-lesioned subjects, the deficiency of septal-lesioned rats in latent inhibition cannot be due to impairment of orienting response habituation. These results, in addition to other septal deficits, were discussed with respect to a theory of septal deficiency which suggests that septal lesions result in an impairment in situations which involve a discontinuity of response and reinforecement.
在实验I中，研究了正常大鼠和隔区损伤大鼠的潜伏抑制效应，即当先前呈现但未强化的刺激随后用作条件刺激时，条件反应习得的延迟现象。与未接受非强化条件刺激呈现的正常动物相比，在条件刺激与电击配对之前接受30次非强化条件刺激呈现的正常动物，在主动回避习得方面出现延迟。同样的操作在隔区损伤大鼠中未能产生这种差异。在实验II中，口渴的正常大鼠和隔区损伤大鼠在饮水时暴露于与实验I中用作条件刺激的相同刺激。正在进行的饮水抑制过程被用作定向反应习惯化的指标。由于在正常大鼠和隔区损伤大鼠之间未发现习惯化差异，隔区损伤大鼠潜伏抑制的缺陷不可能归因于定向反应习惯化的损害。除了其他隔区缺陷外，还根据一种隔区缺陷理论对这些结果进行了讨论，该理论认为隔区损伤会导致在涉及反应和强化不连续性的情况下出现损害。
