[Various disorders of cholesterol metabolism and their effect on the development of experimental arteriosclerosis in rats exposed to carbon disulfide].

Basing on the results of the author's own studies performed in a series of experiments in rats, the author discusses the mechanism of the atherosclerotic effect of CS2. The results of the studies carried out by the author indicated that the disturbances of body cholesterol metabolism (especially the increased rate of cholesterol synthesis and decreased rate of its degradation) contribute to elevation of cholesterol level in blood. The above alterations together with the cholesterol metabolism disturbances due to CS2 emerging directly in the aorta wall aggravate the development of the atherosclerotic changes in the vascular wall. The experimental (biochemical and morphological) evidences on the atherosclerotic effect of CS2 have been provided.