富含脯氨酸的人唾液蛋白的基因多态性
Genetic polymorphism of proline-rich human salivary proteins.
作者信息
Azen E A, Oppenheim F G
出版信息
Science. 1973 Jun 8;180(4090):1067-9. doi: 10.1126/science.180.4090.1067.
In randomly collected saliva samples from 120 Caucasians, 79 Blacks, and 40 Chinese, three phenotypes were observed by electrophoresis in alkaline slab polyacrylamide gels. The proteins showing polymorphism were identical with four previously characterized proline-rich proteins. Inheritance is controlled by two autosomal codominant alleles. The gene frequencies were for Caucasians, Pr(l)=0.73, Pr(2)=0.27; for Blacks, Pr(1)=0.80, Pr(2)=0.20; for Chinese, Pr(l)=0.84, Pr(2)=0.16.
在从120名白种人、79名黑人和40名中国人中随机采集的唾液样本中，通过在碱性平板聚丙烯酰胺凝胶中进行电泳观察到三种表型。显示多态性的蛋白质与四种先前已鉴定的富含脯氨酸的蛋白质相同。遗传由两个常染色体共显性等位基因控制。基因频率在白种人中，Pr(1)=0.73，Pr(2)=0.27；在黑种人中，Pr(1)=0.80，Pr(2)=0.20；在中国人中，Pr(1)=0.84，Pr(2)=0.16。
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