1 Department of Oral Biology, Dental College, University of Manitoba, Winnipeg, MB, Canada.
2 Center for Oral/Head and Neck Oncology Research, Division of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles, CA, USA.
J Dent Res. 2019 Feb;98(2):133-141. doi: 10.1177/0022034518816961.
The objective of this article was to provide an account of some of the developments related to saliva over the first 100 years of the Journal of Dental Research and to outline some of the many biomarkers identified in saliva in the last few years. The first section covers findings in salivary physiology, biochemistry, calcium phosphate chemistry related to saliva, microbiology, and the role of saliva in maintaining oral health. The second section highlights salivary diagnostics, salivaomics, and saliva exosomics in the context of the emerging theme of personalized and precision medicine.
本文旨在介绍《牙研究杂志》创刊 100 年来与唾液相关的一些进展，并概述近年来在唾液中发现的许多生物标志物。第一部分涵盖了唾液生理学、生物化学、与唾液相关的钙磷化学、微生物学以及唾液在维持口腔健康中的作用等方面的发现。第二部分重点介绍了唾液诊断学、唾液组学和唾液外泌体组学，以及个性化和精准医学这一新兴主题的背景。
