Stanciu C, Bennett J R
Gut. 1973 Apr;14(4):275-9. doi: 10.1136/gut.14.4.275.
In 30 patients with gastrooesophageal reflux, intravenous metoclopramide (Maxolon) has been shown to increase the gastrooesophageal sphincter pressure. The rise is dose-related until a maximum pressure, proportional to the resting sphincter tone, is reached. The effect is reversed by atropine. Peristaltic waves are increased in pressure by metoclopramide.In 18 patients with gastrooesophageal reflux intravenous metoclopramide diminished the frequency of reflux episodes and increased the rate at which the oesophagus emptied itself of an acid load.
在30例胃食管反流患者中，静脉注射甲氧氯普胺（胃复安）已被证明可增加胃食管括约肌压力。这种升高与剂量相关，直到达到与静息括约肌张力成正比的最大压力。阿托品可逆转这种作用。甲氧氯普胺可增加蠕动波的压力。在18例胃食管反流患者中，静脉注射甲氧氯普胺减少了反流发作的频率，并增加了食管排空酸负荷的速率。
