Pilger E, Schmid P, Goebel R
Med Klin. 1979 Jun 1;74(22):859-65.
24 diabetics without any complications were subjected to an exercise test before and after biguanid therapy. The schedule of the physical strain was a modification of the Kaltenbach diagram. Changes of lactate, pyruvate, pH-standard bicarbonate and base excess values were analysed. Additionally to antidiabetical therapy each of the 8 patients was given either metformin or buformin or phenformin now. Each one of the biguanid derivates induced a rise of the lactate level before and after the exercise test. Phenformin showed the greatest influence on the lactate metabolism, metformin the smallest. Reasons causing the lactogene effect and the quantitative differences of the biguanides are discussed.
24名无任何并发症的糖尿病患者在双胍类药物治疗前后接受了运动测试。体力负荷方案是对卡尔滕巴赫图表的一种修改。分析了乳酸、丙酮酸、pH标准碳酸氢盐和碱剩余值的变化。除抗糖尿病治疗外，现在8名患者中的每一位分别给予二甲双胍、丁双胍或苯乙双胍。每种双胍类衍生物在运动测试前后均引起乳酸水平升高。苯乙双胍对乳酸代谢的影响最大，二甲双胍最小。讨论了导致乳酸生成效应的原因以及双胍类药物的定量差异。
