Murray M J, Murray N J, Murray A B, Murray M B
Lancet. 1975 Mar 22;1(7908):653-4. doi: 10.1016/s0140-6736(75)91758-4.
During the Central African (Sahelian) drought, attacks of falciparum malaria were common in patients and their relatives shortly after their arrival in a hospital in Eastern Niger. A prospective study of 72 adult patients not admitted for malaria and 109 accompanying relatives was undertaken to investigate this observation. 23 attacks occurred in patients and 51 in relatives, with a peak frequency five days after arrival. On arrival, parasitaemia was low but reached a maximum by five days. Serum-iron and percentage saturation of transferrin were moderately increased initially, rose dramatically within forty-eight hours with near maximum saturation, and were falling by the fifth day. It is suggested that the early hyperferraemia, apparently related to refeeding, led to rapid multiplication of existing parasites and attacks of malaria. The results of experimental malarial infection of Wistar rats, half of which had been given intramuscular iron, supported this hypothesis.
在中非（萨赫勒地区）干旱期间，恶性疟原虫疟疾发作在患者及其亲属抵达尼日尔东部一家医院后不久很常见。对72名未因疟疾入院的成年患者和109名陪同亲属进行了一项前瞻性研究，以调查这一现象。患者中发生了23次发作，亲属中发生了51次发作，抵达后五天发作频率达到峰值。抵达时，寄生虫血症较低，但到第五天达到最大值。血清铁和转铁蛋白饱和度百分比最初适度增加，在48小时内急剧上升至接近最大饱和度，并在第五天下降。有人认为，早期高铁血症显然与重新进食有关，导致现有寄生虫迅速繁殖和疟疾发作。对一半接受肌肉注射铁剂的Wistar大鼠进行实验性疟疾感染的结果支持了这一假设。
