Nicholas A H, Vienne M, van den Berghe H
Mutat Res. 1979 Jun;67(2):167-72. doi: 10.1016/0165-1218(79)90128-9.
Because malathion is a widely used organophosphorous insecticide, the effects of non-toxic concentrations (2.5--40 micrograms/ml) on sister-chromatid exchange (SCE) frequencies were determined. Human fetal fibroblasts were exposed once or twice to malathion, with 20 h between exposures. A single exposure to a concentration of 40 micrograms/ml resulted in a highly significant increase in the number of SCEs. After a double exposure, a concentration of 20 micrograms/ml induced an even greater increase in SCE frequencies. Comparison of Sce frequencies after single and double exposures indicated a cumulative effect; the number of exchanges at concentrations of 5 micrograms/ml or higher was significantly greater after the double exposure. An analysis of SCEs by chromosome group showed that exchanges were distributed approximately according to chromosome length.
由于马拉硫磷是一种广泛使用的有机磷杀虫剂，因此测定了无毒浓度（2.5 - 40微克/毫升）对姐妹染色单体交换（SCE）频率的影响。人胎儿成纤维细胞单次或两次暴露于马拉硫磷，两次暴露之间间隔20小时。单次暴露于40微克/毫升的浓度会导致SCE数量显著增加。两次暴露后，20微克/毫升的浓度会使SCE频率有更大的增加。单次和两次暴露后Sce频率的比较表明存在累积效应；两次暴露后，5微克/毫升或更高浓度下的交换次数显著更多。按染色体组对SCE进行分析表明，交换大致根据染色体长度分布。
