Mendelson J H, Mello N K
Science. 1973 Jun 29;180(4093):1372-4. doi: 10.1126/science.180.4093.1372.
Alcohol addicts with a primary type IV hyperlipoproteinemia show a striking elevation of triglycerides in the serum during long periods of alcohol consumption as compared with controls, without an accompanying significant increase in free fatty acids in the serum. These data suggest that this genetically related lipid abnormality may be a significant factor in the pathogenesis of alcohol hyperlipemia and the alcohol-induced fatty liver.
患有原发性IV型高脂蛋白血症的酗酒者在长期饮酒期间,与对照组相比,血清甘油三酯显著升高,而血清游离脂肪酸却没有相应显著增加。这些数据表明,这种与遗传相关的脂质异常可能是酒精性高脂血症和酒精性脂肪肝发病机制中的一个重要因素。