痛风中高甘油三酯血症的机制与治疗
Mechanism and treatment of hypertriglyceridaemia in gout.
作者信息
Gibson T, Kilbourn K, Horner I, Simmonds H A
出版信息
Ann Rheum Dis. 1979 Feb;38(1):31-5. doi: 10.1136/ard.38.1.31.
Abstract
Using the Intralipid lipid tolerance test we could not demonstrate any direct effect of serum triglyceride on uric acid or any influence of hyperuricaemia on triglyceride removal. This result supports previous studies suggesting that hyperuricaemia and hypertriglyceridaemia are linked through the association of obesity and alcohol excess rather than a direct cause and effect mechanism. It was possible to demonstrate significant reductions of serum triglyceride in patients with gout by reducing either their alcohol intake or body weight. Reduction of serum uric acid by probenecid had no effect on serum triglyceride or cholesterol. Similarly, allopurinol had no significant effect on serum triglyceride, but a significant fall of serum cholesterol was observed.
摘要
使用脂肪乳剂耐脂试验，我们无法证明血清甘油三酯对尿酸有任何直接影响，也无法证明高尿酸血症对甘油三酯清除有任何影响。这一结果支持了先前的研究，表明高尿酸血症和高甘油三酯血症是通过肥胖和过量饮酒的关联联系在一起的，而非直接的因果机制。通过减少酒精摄入量或体重，可以证明痛风患者的血清甘油三酯显著降低。丙磺舒降低血清尿酸对血清甘油三酯或胆固醇没有影响。同样，别嘌醇对血清甘油三酯没有显著影响，但观察到血清胆固醇显著下降。
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