Yousufzai S Y, Siddiqi M, Abdullah A K
Lipids. 1976 Jul;11(7):526-9. doi: 10.1007/BF02532897.
Oral administration of l g of 3-hydroxy-3-methylglutaric acid (HMG) before the ingestion of whiskey and a fatty meal markedly reduced the elevation of serum triglycerides, beta-lipoproteins, phospholipids, and cholesterol in man. In rats receiving an ethanol and corn oil mixture, HMG also inhibited the increase in postprandial serum and liver lipids. A comparative study of HMG and nicotinic acid in rats showed that, therapeutically, 50 mg MHG/kg body weitht is equivalent to 200 mg nicotinic acid/kg body weight in offering almost total protection against lipemic effects of ethanol.
在摄入威士忌和高脂餐之前口服1克3-羟基-3-甲基戊二酸（HMG），可显著降低人体血清甘油三酯、β-脂蛋白、磷脂和胆固醇的升高。在接受乙醇和玉米油混合物的大鼠中，HMG也抑制了餐后血清和肝脏脂质的增加。对大鼠中HMG和烟酸的一项比较研究表明，在治疗上，50毫克HMG/千克体重相当于200毫克烟酸/千克体重，几乎能完全预防乙醇的致脂血症作用。
