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48,XXXY的起源:Xg血型的证据。

Origin of 48,XXXY: the evidence of the Xg blood groups.

作者信息

Pfeiffer R A, Sanger R

出版信息

J Med Genet. 1973 Jun;10(2):142-3. doi: 10.1136/jmg.10.2.142.

DOI:10.1136/jmg.10.2.142
PMID:4714580
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1013004/
Abstract

A third family is reported in which the Xg groups give information about the origin of an XXXY member: successive non-disjunction at the first and second paternal meiotic divisions is much the most likely cause. In the two previous informative families successive non-disjunction at maternal meiotic divisions was the most likely cause. An enquiry showed the average age of 29 fathers at the birth of XXXY sons to be 32-41 years.

摘要

据报道,有第三个家族,其中Xg血型群体为一名XXXY成员的起源提供了信息:最可能的原因是父本减数分裂第一次和第二次连续发生不分离。在前两个提供信息的家族中,最可能的原因是母本减数分裂连续发生不分离。一项调查显示,29位XXXY儿子出生时父亲的平均年龄为32至41岁。

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引用本文的文献

1
Parental origin of the extra chromosomes in polysomy X.X染色体多体中额外染色体的亲本来源。
Hum Genet. 1994 Oct;94(4):423-6. doi: 10.1007/BF00201605.

本文引用的文献

1
SUCCESSIVE NON-DISJUNCTION AT FIRST AND SECOND MEIOTIC DIVISION OF SPERMATOGENESIS: EVIDENCE OF CHROMOSOMES AND XG.精子发生过程中第一次和第二次减数分裂的连续不分离:染色体和XG的证据
Cytogenetics. 1964;3:334-41. doi: 10.1159/000129822.
2
Apert's syndrome (a type of acrocephalosyndactyly)-observations on a British series of thirty-nine cases.阿佩尔综合征(一种尖头并指畸形)——对英国39例病例的观察
Ann Hum Genet. 1960 May;24:151-64. doi: 10.1111/j.1469-1809.1959.tb01728.x.
3
Cytogenetic analysis of a boy with the XXXY syndrome: origin of the X-chromosomes.一名患有XXXY综合征男孩的细胞遗传学分析:X染色体的起源
Pediatrics. 1970 Apr;45(4):677-86.
4
Xg groups and sex abnormalities in people of northern European ancestry.北欧血统人群中的Xg血型组与性异常
J Med Genet. 1971 Dec;8(4):417-26. doi: 10.1136/jmg.8.4.417.