无胎儿型血红蛋白的哺乳动物围产期2,3-二磷酸甘油酸及氧亲和力的变化
Perinatal changes of 2,3-diphosphoglycerate and oxygen affinity in mammals not having fetal type hemoglobins.
作者信息
Bard H, Shapiro M
出版信息
Pediatr Res. 1979 Mar;13(3):167-9. doi: 10.1203/00006450-197903000-00006.
The interrelationship of 2,3-diphosphoglycerate (2,3-DPG) and P50 levels during the fetal and postnatal life were determined in two mammalian species which do not have a switchover of hemoglobin type at the end of their fetal development. In the guinea pig and rabbit, the 2,3-DPG levels remain low during fetal life and increase only after birth remaining elevated throughout adult life. The adult levels were reached at 2 days of age in the guinea pig and the 20th day in rabbit. Fetal P50 values increased only after birth, paralleling the rise in the 2,3-DPG. The rapidity of the postnatal rise in 2,3-DPG and decrease in P50 appears related to the maturity of the newborn animal at birth in these species.
在两种在胎儿发育末期不存在血红蛋白类型转换的哺乳动物中，测定了胎儿期和出生后2,3 - 二磷酸甘油酸（2,3 - DPG）与P50水平之间的相互关系。在豚鼠和兔子中，胎儿期2,3 - DPG水平较低，仅在出生后升高，并在成年期持续保持较高水平。豚鼠在出生后2天达到成年水平，兔子在出生后第20天达到成年水平。胎儿期的P50值仅在出生后升高，与2,3 - DPG的升高平行。在这些物种中，出生后2,3 - DPG升高和P50降低的速度似乎与新生动物出生时的成熟度有关。
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