肝脏疾病中的骨骼肌血流与神经血管反应性
Skeletal muscle blood flow and neurovascular reactivity in liver disease.
作者信息
Lunzer M, Newman S P, Sherlock S
出版信息
Gut. 1973 May;14(5):354-9. doi: 10.1136/gut.14.5.354.
Abstract
There was no significant difference in forearm muscle blood flow, measured by the clearance of (133)Xenon when 38 patients with liver disease were compared with 38 normal subjects. Patients with a clinically hyperdynamic circulation, finger clubbing, and previous portocaval anastomoses were included in the study. The changes in forearm skeletal muscle blood flow and pulse rate caused by a head-up tilt of 70 degrees were measured in 15 patients with chronic liver disease and 15 age-matched controls. Head-up tilting resulted in significantly less peripheral vasoconstriction and tachycardia in the group with liver disease than in the control group. These results suggest an impairment of baroreceptor-mediated sympathetic reactivity in liver disease. Such a defect might explain the relative rarity of hypertension in patients with cirrhosis.
摘要
在比较38例肝病患者和38例正常受试者时，通过（133）氙清除率测量的前臂肌肉血流量没有显著差异。本研究纳入了具有临床高动力循环、杵状指和既往门腔静脉吻合术的患者。在15例慢性肝病患者和15例年龄匹配的对照组中，测量了70度头高位倾斜引起的前臂骨骼肌血流量和脉搏率变化。与对照组相比，肝病组头高位倾斜导致的外周血管收缩和心动过速明显较少。这些结果表明肝病患者压力感受器介导的交感反应受损。这种缺陷可能解释了肝硬化患者高血压相对少见的原因。
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