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CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, NSC-79037) in the treatment of cancer. Phase II study.

作者信息

Hoogstraten B, Gottlieb J A, Caoili E, Tucker W G, Talley R W, Haut A

出版信息

Cancer. 1973 Jul;32(1):38-43. doi: 10.1002/1097-0142(197307)32:1<38::aid-cncr2820320105>3.0.co;2-i.

DOI:10.1002/1097-0142(197307)32:1<38::aid-cncr2820320105>3.0.co;2-i
PMID:4716783
Abstract
摘要

相似文献

1
CCNU (1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea, NSC-79037) in the treatment of cancer. Phase II study.环己亚硝脲（1-（2-氯乙基）-3-环己基-1-亚硝基脲，NSC-79037）治疗癌症。II期研究。
Cancer. 1973 Jul;32(1):38-43. doi: 10.1002/1097-0142(197307)32:1<38::aid-cncr2820320105>3.0.co;2-i.
2
Combination chemotherapy with adriamycin (NSC-123127) and 1-(2-chloroethyl)-3-cyclohexyl 1-nitrosourea (CCNU; NSC-79037).阿霉素（NSC-123127）与1-(2-氯乙基)-3-环己基-1-亚硝基脲（CCNU；NSC-79037）联合化疗。
Cancer Chemother Rep. 1973 Nov-Dec;57(4):437-45.
3
Phase II study of the effect of methyl-CCNU (NSC-95441) on bronchogenic carcinoma.
Cancer Chemother Rep 3. 1973 Mar;4(2):257-9.
4
Trial of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; NSC-79037) in advanced bronchogenic carcinoma 1,2,3.
Oncology. 1975;31(5-6):288-92. doi: 10.1159/000225035.
5
Physiologic disposition of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) and 1-(2-chloroethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (Me CCNU) in man.1-（2-氯乙基）-3-环己基-1-亚硝基脲（CCNU）和1-（2-氯乙基）-3-（4-甲基环己基）-1-亚硝基脲（Me CCNU）在人体中的生理处置
Cancer. 1973 May;31(5):1154-6. doi: 10.1002/1097-0142(197305)31:5<1154::aid-cncr2820310517>3.0.co;2-b.
6
A trial of 1-(2-chlorethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea in the treatment of patients with advanced gastro-intestinal cancer.1-（2-氯乙基）-3-（4-甲基环己基）-1-亚硝基脲治疗晚期胃肠道癌患者的试验
Br J Surg. 1974 Dec;61(12):950. doi: 10.1002/bjs.1800611206.
7
Initial clinical trials with methyl-CCNU 1-(2-chlorethyl)-3-(4-methyl cyclohexyl)-1-nitrosourea (MeCCNU).
Cancer. 1973 May;31(5):1164-9. doi: 10.1002/1097-0142(197305)31:5<1164::aid-cncr2820310519>3.0.co;2-4.
8
Role of a nitrosourea (CCNU, NSC-79037) in advanced nonhematologic cancer.亚硝基脲（环己亚硝脲，NSC - 79037）在晚期非血液系统癌症中的作用。
Cancer Chemother Rep. 1974 May-Jun;58(3):421-4.
9
Sequential 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) and 5-fluorouracil (NSC 19893) therapy of gastrointestinal cancer.胃肠道癌的序贯1-(2-氯乙基)-3-环己基-1-亚硝基脲（NSC 79037）和5-氟尿嘧啶（NSC 19893）治疗
Cancer Res. 1972 Jun;32(6):1280-2.
10
Phase II evaluation of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU; NSC-409962) in patients with solid tumors.1,3-双（2-氯乙基）-1-亚硝基脲（卡莫司汀；NSC-409962）用于实体瘤患者的II期评估。
Cancer Chemother Rep. 1972 Dec;56(6):787-90.

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First-principles study of a SiC nanosheet as an effective material for nitrosourea and carmustine anti-cancer drug delivery.碳化硅纳米片作为亚硝基脲和卡莫司汀抗癌药物递送有效材料的第一性原理研究
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Surface adsorption of nitrosourea on pristine and doped (Al, Ga and In) boron nitride nanosheets as anticancer drug carriers: the DFT and COSMO insights.作为抗癌药物载体的亚硝基脲在原始及掺杂（铝、镓和铟）的氮化硼纳米片上的表面吸附：密度泛函理论和导体屏蔽模型见解
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From the Broad Phase II Trial to Precision Oncology: A Perspective on the Origins of Basket and Umbrella Clinical Trial Designs in Cancer Drug Development.
从广谱二期临床试验到精准肿瘤学：癌症药物研发中篮子和伞式临床试验设计起源的观点。
Cancer J. 2019 Jul/Aug;25(4):245-253. doi: 10.1097/PPO.0000000000000386.
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Hepatotoxicity Secondary to Chemotherapy.化疗相关肝毒性。
J Clin Transl Hepatol. 2014 Jun;2(2):95-102. doi: 10.14218/JCTH.2014.00011. Epub 2014 Jun 15.
5
Low apparent risk of CCNU (lomustine)-associated clinical hepatotoxicity in cats.猫中洛莫司汀（CCNU）相关临床肝毒性的表观风险较低。
J Feline Med Surg. 2012 Dec;14(12):871-5. doi: 10.1177/1098612X12453836. Epub 2012 Jul 6.
6
Extreme drug resistance in primary brain tumors: in vitro analysis of 64 resection specimens.原发性脑肿瘤中的极端耐药性：64例切除标本的体外分析
J Neurooncol. 2002 Jun;58(2):115-23. doi: 10.1023/a:1016049111941.
7
Chemotherapy for high-grade gliomas.高级别胶质瘤的化疗
Br J Cancer. 2000 Apr;82(8):1371-80. doi: 10.1054/bjoc.1999.1075.
8
Inhibition of O6-alkylguanine-DNA alkyltransferase in animal and human ovarian tumor cell lines by O6-benzylguanine and sensitization to BCNU.O6-苄基鸟嘌呤对动物和人类卵巢肿瘤细胞系中O6-烷基鸟嘌呤-DNA烷基转移酶的抑制作用及对卡莫司汀的增敏作用。
Cancer Chemother Pharmacol. 1995;35(3):262-6. doi: 10.1007/BF00686559.
9
The hepatotoxicity of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) in rats. Ultrastructural evidence of a delayed microtubular toxicity.
Cancer Chemother Pharmacol. 1988;22(2):153-62. doi: 10.1007/BF00257314.