Etling N, Vielh J P
Nouv Presse Med. 1979 May 5;8(20):1647-8.
The mean of total iodine levels in amniotic fluid samples is 7.8 ng/ml during the middle of pregnancy and 4.4 ng at the end. On about 200 samples collected at random from high risk pregnant women, 14% fluid contain iodine load. This iodine excess comes from water-soluble iodinated drugs administrated to the pregnant women; most are less than 300 ng/ml but 24 hours after urography the load reaches 80,000 times the mean value. Biochemical analyses have shown the iodine excess was iodide, easely released. In our study no neonatal hypothyroidism was noticed probably because that degradation. However administration of any iodinated drug to pregnant women may be a risk to the fetus.
羊水样本中总碘水平的平均值在妊娠中期为7.8纳克/毫升，在妊娠末期为4.4纳克。在从高危孕妇中随机采集的约200份样本中，14%的羊水含有碘负荷。这种碘过量来自给予孕妇的水溶性碘化药物；大多数低于300纳克/毫升，但在尿路造影后24小时，负荷达到平均值的80000倍。生化分析表明，过量的碘是碘化物，易于释放。在我们的研究中，未发现新生儿甲状腺功能减退，可能是因为这种降解。然而，给孕妇使用任何碘化药物都可能对胎儿有风险。
