Etling N, Gehin-Fouque F, Vielh J P, Gautray J P
Obstet Gynecol. 1979 Mar;53(3):376-80.
Determinations of total iodine content, levels of thyroxine (T4) and triiodothyronine (T3), and protein concentrations were made on amniotic fluid. A total of 218 samples obtained at various stages of pregnancy, from both normal and pathological pregnancies, were studied. Normal values for the iodine and hormone concentrations are presented. Several amniotic fluid samples showed greatly elevated iodine levels, thought to be the result of maternal iodine intake. This study demonstrated that such elevated levels can be produced by urography with an iodinated medium, by thyroid extract therapy, and by vaginal therapy with an iodinated agent. Levels of T4 and T3 in amniotic fluid decreased slightly from the second to the third trimester and were unrelated to the total iodine levels. Despite reports in the literature of fetal hypothyroidism produced by amniography with a fat-soluble medium, no thyroid defect was observed in this series in the presence of elevated amniotic fluid iodine levels or when a water-soluble iodinated medium was used for amniography.
对羊水进行了总碘含量、甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平以及蛋白质浓度的测定。共研究了218份在妊娠不同阶段获取的样本，这些样本来自正常和病理妊娠。给出了碘和激素浓度的正常值。几份羊水样本显示碘水平大幅升高，认为这是母体碘摄入的结果。该研究表明，使用碘化介质进行尿路造影、甲状腺提取物治疗以及使用碘化剂进行阴道治疗均可导致这种升高。从妊娠中期到晚期，羊水T4和T3水平略有下降，且与总碘水平无关。尽管文献报道了使用脂溶性介质进行羊膜造影会导致胎儿甲状腺功能减退，但在本系列研究中，在羊水碘水平升高或使用水溶性碘化介质进行羊膜造影时，均未观察到甲状腺缺陷。
