Giraud J R, Dugué-Maréchaud M, Fizazi T, de Tourris H, Aubert J
J Gynecol Obstet Biol Reprod (Paris). 1983;12(1):45-9.
The authors approach the question of the risk of fetal and neonatal hypothyroidism when intravenous pyelography is carried out in the pregnant woman. They looked at a continuous series of 15 cases in 7 years, of which 8 were studied retrospectively and 7 prospectively. They did not find any clinical or biological signs of hypothyroidism when the children were from 10 months to 9 years of age at review. The authors approached the reaction of the fetal thyroid to this excess dose of iodine considering what is known about the physiology of this gland in utero and the publications concerning hypothyroidism occurring after prolonged administration of iodine or amniofetography. They conclude that there is probably a temporary disturbance of fetal thyroid function but it does not continue into the neonatal period. All the same, caution is advocated because intravenous urography during pregnancy should be carried out only for very tight indications and the newborn should be carefully examined.
作者探讨了孕妇进行静脉肾盂造影时胎儿及新生儿甲状腺功能减退风险的问题。他们观察了7年间连续的15例病例，其中8例进行回顾性研究，7例进行前瞻性研究。在复查时，当儿童年龄在10个月至9岁之间时，他们未发现任何甲状腺功能减退的临床或生物学迹象。考虑到关于胎儿甲状腺在子宫内的生理学知识以及长期服用碘或羊膜腔造影术后发生甲状腺功能减退的相关文献，作者探讨了胎儿甲状腺对这种过量碘的反应。他们得出结论，胎儿甲状腺功能可能会有暂时的紊乱，但不会持续到新生儿期。尽管如此，仍提倡谨慎行事，因为孕期静脉肾盂造影仅应在非常严格的指征下进行，并且应对新生儿进行仔细检查。
