Bouchard P, Kuttenn F, Nahoul K, Mavier P, Schaison G, Mauvais-Jarvis P
Nouv Presse Med. 1979 May 5;8(20):1651-4.
Deviation of cortisol metabolism in favour of its 6 beta-hydroxylated derivative was demonstrated in two patients with adrenal failure receiving substitution corticosteroid therapy and rifampicin. The existence of a frank increase in the metabolic clearance antipyrin was in favour of an hepatic enzyme induction. After rifampicin treatment was stopped, the 24 hour urinary excretion of 6 beta-OH-F returned to normal, demonstrating the responsability of the drug. This enzyme induction results in a need to increase the dose of hydrocortisone substitution therapy in patients with Addison's disease treated with rifampicin.
在两名接受替代皮质类固醇治疗和利福平治疗的肾上腺功能不全患者中，证实了皮质醇代谢偏向其6β-羟基化衍生物。安替比林代谢清除率明显增加，这有利于肝酶诱导。停用利福平治疗后，6β-OH-F的24小时尿排泄恢复正常，证明了该药物的作用。这种酶诱导导致在用利福平治疗的艾迪生病患者中需要增加氢化可的松替代治疗的剂量。
