Tangedahl T N
Postgrad Med. 1979 Sep;66(3):175-6, 178-9. doi: 10.1080/00325481.1979.11715255.
Gallstone formation is a heterogeneous disease for which supersaturation of bile with cholesterol and hemolysis of RBCs are major driving forces associated with initial formation and growth. Specific risk factors are superimposed on the gradually increasing prevalence of gallstones with age in most populations. Major risk factors associated with cholesterol gallstone formation are American Indian ancestry, female sex, obesity, and ingestion of lithogenic drugs, such as estrogen-containing preparations and clofibrate. Hemolysis and cirrhosis are risk factors for pigment stones.
胆结石形成是一种异质性疾病，胆汁中胆固醇过饱和以及红细胞溶血是其初始形成和生长的主要驱动因素。在大多数人群中，随着年龄增长胆结石患病率逐渐上升，特定风险因素叠加其上。与胆固醇结石形成相关的主要风险因素包括美洲印第安人血统、女性、肥胖以及摄入致石性药物，如含雌激素制剂和氯贝丁酯。溶血和肝硬化是色素结石的风险因素。
