Platteborse R, Hermans C, Loots W, Van Loon J, Van Gorp A, Smet F, Jageneau A
Postgrad Med J. 1979;55 Suppl 1:15-8.
In a study in dogs using ultrasonic transducers to measure degree of pyloric dilatation, it was found that i.v. domperidone (0.35 and 0.7 mg/kg) significantly increased the diameter of the pyloric lumen without affecting the frequency of pyloric relaxations. A subsequent study involving 59 patients referred for upper digestive tract endoscopy, confirmed this increase in diameter of the pylorus which indicates a potential use of domperidone (either i.v. or oral) in the treatment of some forms of dyspepsia characterized by delayed gastric emptying.
在一项利用超声换能器测量犬幽门扩张程度的研究中，发现静脉注射多潘立酮（0.35和0.7毫克/千克）可显著增加幽门管腔直径，而不影响幽门松弛频率。随后一项涉及59例接受上消化道内镜检查患者的研究证实了幽门直径的这种增加，这表明多潘立酮（静脉注射或口服）在治疗某些以胃排空延迟为特征的消化不良形式方面具有潜在用途。
