Reyntjens A J, Niemegeers C J, Van Nueten J M, Laduron P, Heykants J, Schellekens K H, Marsboom R, Jageneau A, Broekaert A, Janssen P A
Arzneimittelforschung. 1978;28(7):1194-6.
The new potent anti-nauseant 5-chloro-1-(1p[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-propyl]-4-piperidinyl)-1.3-dihydro-2H-benzimidazol-2-one (domperidone), which in contrast to available anti-emetics does not provoke extrapyramidal or adrenolytic adverse effects, also enhances gastric emptying motility. Controlled clinical trials have confirmed its prokinetic effects on the stomach and its lack of side-effects, even at high doses. This anti-nauseant appears to be a safe and effective treatment for patients, both adults and children, with dyspepsia or vomiting.
新型强效抗恶心药物5-氯-1-(1-[3-(2,3-二氢-2-氧代-1H-苯并咪唑-1-基)-丙基]-4-哌啶基)-1,3-二氢-2H-苯并咪唑-2-酮（多潘立酮），与现有的止吐药不同，它不会引发锥体外系或肾上腺溶解不良反应，还能增强胃排空动力。对照临床试验已证实其对胃部的促动力作用以及即使高剂量使用时也无副作用。这种抗恶心药物似乎是治疗成人和儿童消化不良或呕吐患者的一种安全有效的疗法。
