Baeyens R, van de Velde E, De Schepper A, Wollaert F, Reyntjens A
Postgrad Med J. 1979;55 Suppl 1:19-23.
One hundred and fifty-six patients referred for barium meal with follow-up examination, participated in a placebo-controlled blind assessment of the effects of domperidone against placebo, on gastric motility and emptying. None of the patients had organic obstruction, had undergone previous gastrointestinal surgery or were currently taking anticholinergic drugs. In one study, patients were randomly given either 10 mg, 20 mg or 50 mg of domperidone or placebo suspension orally 30 minutes prior to barium meal to simulate therapeutic conditions. In a separate study conducted under identical conditions, either 8 mg domperidone or placebo was given intravenously. Domperidone (8 mg i.v. or 20 and 50 mg orally) significantly promoted antral peristalsis and gastric emptying compared to placebo. The results suggest that domperidone improves motor function in the proximal part of the gastrointestinal tract and synchronizes motor function due to its protracted activity.
156名因钡餐检查及后续检查前来就诊的患者参与了一项多潘立酮与安慰剂对照的双盲评估，以研究多潘立酮对安慰剂在胃动力和排空方面的影响。所有患者均无器质性梗阻，未曾接受过胃肠道手术，且当前未服用抗胆碱能药物。在一项研究中，患者在钡餐检查前30分钟随机口服10毫克、20毫克或50毫克多潘立酮或安慰剂混悬液，以模拟治疗情况。在另一项在相同条件下进行的研究中，静脉注射8毫克多潘立酮或安慰剂。与安慰剂相比，多潘立酮（静脉注射8毫克或口服20毫克和50毫克）显著促进胃窦蠕动和胃排空。结果表明，多潘立酮可改善胃肠道近端的运动功能，并因其持久作用使运动功能同步。
