Hodkinson H M, Pomerance A
Postgrad Med J. 1979;55(642):251-4. doi: 10.1136/pgmj.55.642.251.
The factors associated with the development of heart failure and of atrial fibrillation in elderly patients were studied in a prospective clinico-pathological series of 171 cases. Multiple logistic analyses allowed the contributions of multiple factors to be assessed simultaneously. Senile cardiac amyloidosis, ischaemic heart disease and atrial fibrillation were significantly associated with heart failure and had additive effects. Senile cardiac amyloidosis, ischaemic heart disease, mitral valve ballooning and higher age were significantly associated with atrial fibrillation but their additive effects were modified by significant interactions between ischaemic heart disease and mitral valve ballooning (whose effects were multiplicative) and senile cardiac amyloidosis and age (the age effect being confined to those without amyloidosis).
在一项对171例患者的前瞻性临床病理研究中，对老年患者心力衰竭和房颤发生的相关因素进行了研究。多元逻辑分析能够同时评估多种因素的作用。老年心脏淀粉样变性、缺血性心脏病和房颤与心力衰竭显著相关且具有累加效应。老年心脏淀粉样变性、缺血性心脏病、二尖瓣脱垂和高龄与房颤显著相关，但缺血性心脏病和二尖瓣脱垂之间的显著相互作用（其作用为相乘）以及老年心脏淀粉样变性和年龄之间的显著相互作用（年龄效应仅限于无淀粉样变性者）改变了它们的累加效应。
