Denham M J, Pomerance A, Hodkinson H M
Postgrad Med J. 1977 Feb;53(616):66-8. doi: 10.1136/pgmj.53.616.66.
Systolic murmurs present in 129 geriatric patients followed to post-mortem were assessed as mitral or aortic in origin by simple clinical assessment alone. Post-mortem examination contradicted clinical findings in only 2% of cases. Mitral valve pathology, mostly post-inflammatory scarring or mucoid degeneration, was present in 50% of the cases with murmurs. There was a significant correlation between the presence of murmurs, particularly mitral murmurs, and congestive cardiac failure, and there was also a significant correlation with age. A tendency for aortic systolic murmurs to be associated with a higher mean systolic blood pressure was not significant and there was no significant association between systolic murmurs and ischaemic heart disease.
对129例接受尸检的老年患者的收缩期杂音仅通过简单的临床评估判断其起源于二尖瓣或主动脉瓣。尸检检查仅在2%的病例中与临床发现相矛盾。50%有杂音的病例存在二尖瓣病变，主要是炎症后瘢痕形成或黏液样变性。杂音尤其是二尖瓣杂音的存在与充血性心力衰竭之间存在显著相关性，并且与年龄也存在显著相关性。主动脉收缩期杂音与较高平均收缩压相关的趋势并不显著，收缩期杂音与缺血性心脏病之间也无显著关联。
