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病毒干扰的诱导：聚肌苷酸-聚胞苷酸和二乙氨基乙基葡聚糖对抗病毒蛋白活性的影响

Induction of viral interference: effects of poly rI-rC and diethylaminoethyl-dextran on the activity of the antiviral protein.

作者信息

Kalmakoff J, Austin F J

出版信息

Infect Immun. 1973 Jul;8(1):63-7. doi: 10.1128/iai.8.1.63-67.1973.

DOI:10.1128/iai.8.1.63-67.1973
PMID:4718923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC422810/
Abstract

The activity of the antiviral protein induced by various ratios of poly rI.rC and diethylaminoethyl (DEAE)-dextran was studied. It was found that, when large doses of poly rI.rC were used, very little viral interference was observed. This effect was initially attributed to the cells being refractory for production of antiviral protein. Subsequent experiments offered alternative explanations suggesting that, at any given dosage of poly rI.rC, an excess of DEAE-dextran is necessary for the production of viral interference. It is suggested that DEAE-dextran acts by exposing a cell receptor site for poly rI.rC.

摘要

研究了不同比例的聚肌苷酸

聚胞苷酸（poly rI.rC）和二乙氨基乙基（DEAE）-葡聚糖诱导的抗病毒蛋白的活性。结果发现，当使用大剂量的poly rI.rC时，观察到的病毒干扰很少。这种效应最初被归因于细胞对抗病毒蛋白的产生具有抗性。随后的实验提供了其他解释，表明在任何给定剂量的poly rI.rC下，产生病毒干扰都需要过量的DEAE-葡聚糖。有人提出，DEAE-葡聚糖通过暴露细胞上的poly rI.rC受体位点来发挥作用。

相似文献

1
Induction of viral interference: effects of poly rI-rC and diethylaminoethyl-dextran on the activity of the antiviral protein.病毒干扰的诱导：聚肌苷酸-聚胞苷酸和二乙氨基乙基葡聚糖对抗病毒蛋白活性的影响
Infect Immun. 1973 Jul;8(1):63-7. doi: 10.1128/iai.8.1.63-67.1973.
2
Mechanism of the antiviral activity resulting from sequential administration of complementary homopolyribonucleotides to cell cultures.向细胞培养物顺序给予互补同聚核糖核苷酸产生抗病毒活性的机制。
J Virol. 1972 May;9(5):721-31. doi: 10.1128/JVI.9.5.721-731.1972.
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Enhancement of interferon production in vitro: a property of tilorone-poly rL:rC/DEAE-Dextran.体外干扰素产生的增强：泰洛龙-聚rL:rC/DEAE-葡聚糖的一种特性。
Proc Soc Exp Biol Med. 1975 Apr;148(4):1044-7. doi: 10.3181/00379727-148-38685.
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The effect of combination of different inducers on the refractory state in interferon production.不同诱导剂组合对干扰素产生中难治状态的影响。
Acta Virol. 1976 Feb;20(1):15-22.
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The role of interferon in the protective effect of a synthetic double-stranded polyribonucleotide against intranasal vesicular stomatitis virus challenge in mice.干扰素在合成双链多聚核糖核苷酸对小鼠鼻内接种水泡性口炎病毒攻击的保护作用中的角色。
J Clin Invest. 1970 Aug;49(8):1565-77. doi: 10.1172/JCI106374.
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J Interferon Res. 1990 Oct;10(5):461-8. doi: 10.1089/jir.1990.10.461.
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[Effect of diethylaminoethyl-dextran on the antiviral activity of polyinosinic-polycytidylic acid complex in tissue culture].[二乙氨基乙基葡聚糖对聚肌苷酸-聚胞苷酸复合物在组织培养中抗病毒活性的影响]
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Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid.干扰素合成的调控：二乙氨基乙基葡聚糖对聚肌苷酸-聚胞苷酸诱导作用的影响
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Interferon production and resistance to viral infection induced by poly I-poly C in chick embryo cells. II. Lack of enhancement by DEAE-dextran.鸡胚细胞中聚肌苷酸-聚胞苷酸诱导的干扰素产生及对病毒感染的抗性。II. 葡聚糖硫酸酯钠无增强作用。
Jpn J Microbiol. 1975 Feb;19(1):65-8. doi: 10.1111/j.1348-0421.1975.tb00848.x.
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Synthesis of poly(A) sequences in poxvirus-infected cells treated with interferon or poly(rI)-poly(rC).在经干扰素或聚肌苷酸-聚胞苷酸处理的痘病毒感染细胞中多聚腺苷酸序列的合成
Virology. 1974 Feb;57(2):570-3. doi: 10.1016/0042-6822(74)90196-2.

引用本文的文献

1
Effects of ionenes on interferon induction by poly(inosinic acid) . poly(cytidylic acid).紫罗精对聚肌苷酸-聚胞苷酸诱导干扰素的影响
Antimicrob Agents Chemother. 1977 Apr;11(4):756-9. doi: 10.1128/AAC.11.4.756.

本文引用的文献

1
Interferon induction increased through chemical modification of a synthetic polyribonucleotide.通过对合成多聚核糖核苷酸进行化学修饰，干扰素诱导作用增强。
Science. 1969 Sep 12;165(3898):1137-9. doi: 10.1126/science.165.3898.1137.
2
Mechanisms of DEAE-dextran enhancement of polynucleotide induction of interferon.二乙氨基乙基葡聚糖增强多核苷酸诱导干扰素的机制。
Proc Soc Exp Biol Med. 1971 Apr;136(4):1111-4. doi: 10.3181/00379727-136-35440.
3
The specificity of interferon induction in chick embryo cells by helical RNA.螺旋状RNA在鸡胚细胞中诱导干扰素的特异性。
Proc Natl Acad Sci U S A. 1969 May;63(1):160-7. doi: 10.1073/pnas.63.1.160.
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The synthesis of poxvirus-specific RNA in interferon-treated cells.干扰素处理的细胞中痘病毒特异性RNA的合成。
Virology. 1972 Apr;48(1):59-70. doi: 10.1016/0042-6822(72)90114-6.
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Interferon inhibits viral protein synthesis in L cells infected with vaccinia virus.干扰素可抑制感染牛痘病毒的L细胞中的病毒蛋白合成。
Nature. 1972 Aug 18;238(5364):385-8. doi: 10.1038/238385a0.
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Whataroa virus, a group A arbovirus isolated in South Westland, New Zealand.瓦塔罗阿病毒，一种在新西兰西南地区分离出的A组虫媒病毒。
Am J Trop Med Hyg. 1967 May;16(3):371-3. doi: 10.4269/ajtmh.1967.16.371.
7
Control of interferon synthesis: effect of diethylaminoethyl-dextran on induction by polyinosinic-polycytidylic acid.干扰素合成的调控：二乙氨基乙基葡聚糖对聚肌苷酸-聚胞苷酸诱导作用的影响
J Virol. 1972 Oct;10(4):614-21. doi: 10.1128/JVI.10.4.614-621.1972.
8
Accentuation of interferon production by metabolic inhibitors and its dependence on protein synthesis.代谢抑制剂对干扰素产生的增强作用及其对蛋白质合成的依赖性。
Virology. 1971 Jun;44(3):503-9. doi: 10.1016/0042-6822(71)90363-1.
9
Origin and possible mode of action of a tissue antagonist of interferon.干扰素组织拮抗剂的起源及可能的作用方式。
Nat New Biol. 1972 Jan 12;235(54):47-8. doi: 10.1038/newbio235047a0.
10
The DEAE dextran:polyriboinosinate-polyribocytidylate complex: physical properties and interferon induction.二乙氨基乙基葡聚糖：聚肌苷酸-聚胞苷酸复合物：物理性质与干扰素诱导
Virology. 1971 Sep;45(3):777-81. doi: 10.1016/0042-6822(71)90194-2.