Mosnaim A D, Karoum F, Zeller A, Callaghan O H, Singh S P, Wolf M E
Clin Chim Acta. 1982 Dec 23;126(3):237-42. doi: 10.1016/0009-8981(82)90297-2.
The activity of blood platelets monoamine oxidase (MAO) was significantly reduced in a group of insulin-dependent diabetics when compared to sex- and age-matched controls. This enzymatic change was accompanied by a dramatic increase in the plasma levels of phenylethylamine, whereas no significant changes were observed for the concentration of either p-tyramine or phenylethanolamine. Levels of the o- and m-isomers of tyramine were below detectable limits (less than 0.050 ng/ml). A possible role of the MAO/monoamine system in the pathophysiology of diabetes is discussed.
与年龄和性别匹配的对照组相比，一组胰岛素依赖型糖尿病患者血小板单胺氧化酶（MAO）的活性显著降低。这种酶活性的变化伴随着血浆中苯乙胺水平的显著升高，而对酪胺或苯乙醇胺的浓度则未观察到显著变化。酪胺的邻位和间位异构体水平低于检测限（小于0.050 ng/ml）。本文讨论了MAO/单胺系统在糖尿病病理生理学中的可能作用。
