Antón D N, Orce L V
Mol Gen Genet. 1976 Feb 27;144(1):97-105. doi: 10.1007/BF00277311.
Two strains independently isolated in Salmonella typhimurium display abnormal autolytic activity when nutrient broth becomes alkaline. They also show increased sensitivity to deoxycholate, EDTA, and sodium dodecyl sulfate. Response to acridine orange remains normal. In both strains a single stable mutation is responsible for all the changes. The same gene, called envD, appears to be involved in both mutant strains. envD has been located at minute 33 of the Salmonella genetic map, between markers sucA and nadA, very close to the latter. envD also affects morphological characteristics of the cells. Many mutant cells are shorter than wild type bacteria, and appear frequently associated in short chains of 4 to 10 cells. Furthermore, envD mutants display division by septation under conditions that preclude its observation in wild type strains.
在鼠伤寒沙门氏菌中独立分离出的两株菌株，当营养肉汤变为碱性时，表现出异常的自溶活性。它们对脱氧胆酸盐、乙二胺四乙酸（EDTA）和十二烷基硫酸钠也表现出更高的敏感性。对吖啶橙的反应保持正常。在这两株菌株中，单个稳定突变导致了所有这些变化。同一基因，称为envD，似乎在这两个突变菌株中都有涉及。envD已定位在沙门氏菌遗传图谱的33分钟处，位于标记sucA和nadA之间，非常靠近后者。envD也影响细胞的形态特征。许多突变细胞比野生型细菌短，并且经常以4至10个细胞的短链形式出现。此外，envD突变体在野生型菌株中无法观察到分隔的条件下仍通过分隔进行分裂。
