抗炎药物引起的豚鼠紫外线反应的延迟表现。

Delayed manifestation of ultraviolet reaction in the guinea-pig caused by anti-inflammatory drugs.

作者信息

Gupta N, Levy L

出版信息

Br J Pharmacol. 1973 Feb;47(2):240-8. doi: 10.1111/j.1476-5381.1973.tb08321.x.

DOI:10.1111/j.1476-5381.1973.tb08321.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1776544/

Abstract

Exposure of depilated skin of guinea-pig to ultraviolet (u.v.) light for 20 s produces a prolonged inflammatory response.2. The erythaema becomes evident within 15-30 min after the exposure and progressively increases in intensity reaching its maximum by 4-6 hours. The erythaema persists over 24 hours.3. Increase in vascular permeability is biphasic with an early short-lived rise peaking at 0.5 h and a prolonged secondary response peaking at 9-12 h and lasting over 48 hours.4. In presence of aspirin, phenylbutazone and indomethacin, administered prior to u.v. exposure, the inflammatory reaction is partially suppressed, depending upon the dose. The drugs are ineffective in aborting or minimizing the response when given after the inflammation is established. Corticosteroids fail to influence the u.v. inflammation in this test. The significance of these findings is discussed.

摘要

将豚鼠脱毛后的皮肤暴露于紫外线（UV）下20秒会产生持续时间较长的炎症反应。
红斑在暴露后15 - 30分钟内变得明显，并逐渐增强，在4 - 6小时达到最大值。红斑持续超过24小时。
血管通透性增加呈双相性，早期短暂升高在0.5小时达到峰值，继发性反应延长，在9 - 12小时达到峰值并持续超过48小时。
在紫外线暴露前给予阿司匹林、保泰松和吲哚美辛，炎症反应会部分受到抑制，这取决于剂量。当炎症形成后给药，这些药物在终止或减轻反应方面无效。在该试验中，皮质类固醇未能影响紫外线炎症。讨论了这些发现的意义。