乙酰乙酸与脑脂肪生成：大鼠脑可溶性部分中乙酰乙酰辅酶A合成酶的发育模式
Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.
作者信息
Buckley B M, Williamson D H
出版信息
Biochem J. 1973 Mar;132(3):653-6. doi: 10.1042/bj1320653.
Abstract
The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.
摘要
据报道，大鼠脑细胞溶胶中存在乙酰乙酰辅酶A合成酶。该酶与细胞溶胶中的乙酰乙酰辅酶A硫解酶偶联，可为脂肪生成和胆固醇合成提供乙酰辅酶A，而无需线粒体参与。这种新的乙酰乙酸利用途径在发育中的大脑中可能很重要。
相似文献
1
Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.
Biochem J. 1973 Mar;132(3):653-6. doi: 10.1042/bj1320653.
2
The regulation of acetoacetyl-CoA synthetase activity by modulators of cholesterol synthesis in vivo and the utilization of acetoacetate for cholesterogenesis.
J Biol Chem. 1984 Dec 10;259(23):14548-53.
3
A survey of enzymes which generate or use acetoacetyl thioesters in rat liver.
J Biol Chem. 1983 Apr 25;258(8):4725-33.
4
Activities of enzymes of acetoacetate metabolism in rat brown adipose tissue during development.
Biochem J. 1985 Nov 1;231(3):773-5. doi: 10.1042/bj2310773.
5
Lipogenesis from ketone bodies in the isolated perfused rat liver. Evidence for the cytosolic activation of acetoacetate.
J Biol Chem. 1982 Apr 10;257(7):3434-40.
6
A radiochemical assay for acetoacetyl-CoA synthetase.
Anal Biochem. 1985 Sep;149(2):358-64. doi: 10.1016/0003-2697(85)90583-4.
7
Activities of 3-oxo acid-CoA transferase and acetoacetyl-CoA synthetase in brain and liver of the developing chick.
Brain Res. 1981 Aug;254(1):89-96. doi: 10.1016/0165-3806(81)90061-4.
8
Acetoacetyl-coenzyme A synthetase activity in rat liver cytosol: a regulated enzyme in lipogenesis.
Biochem Biophys Res Commun. 1982 Jun 15;106(3):856-62. doi: 10.1016/0006-291x(82)91789-2.
9
Role of acetoacetyl-CoA synthetase in acetoacetate utilization by tumor cells.
Cancer Biochem Biophys. 1984 Jun;7(2):101-7.
10
Acetoacetate metabolism in rat brain. Development of acetoacetyl-coenzyme A deacylase and 3-hydroxy-3-methylglutaryl-coenzyme A synthase.
Biochem J. 1978 Dec 15;176(3):951-8. doi: 10.1042/bj1760951.
引用本文的文献
1
Identifying MSMO1, ELOVL6, AACS, and CERS2 related to lipid metabolism as biomarkers of Parkinson's disease.
Sci Rep. 2024 Jul 30;14(1):17478. doi: 10.1038/s41598-024-68585-3.
2
Does Ketogenic Diet Used in Pregnancy Affect the Nervous System Development in Offspring?─FTIR Microspectroscopy Study.
ACS Chem Neurosci. 2023 Aug 2;14(15):2775-2791. doi: 10.1021/acschemneuro.3c00331. Epub 2023 Jul 20.
3
The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain.
Front Cell Neurosci. 2018 Jul 10;12:169. doi: 10.3389/fncel.2018.00169. eCollection 2018.
4
Early and Late Pathomechanisms in Alzheimer's Disease: From Zinc to Amyloid-β Neurotoxicity.
Neurochem Res. 2017 Mar;42(3):891-904. doi: 10.1007/s11064-016-2154-z. Epub 2016 Dec 30.
5
Acetoacetyl-CoA synthetase activity is controlled by a protein acetyltransferase with unique domain organization in Streptomyces lividans.
Mol Microbiol. 2013 Jan;87(1):152-67. doi: 10.1111/mmi.12088. Epub 2012 Nov 30.
6
Utilization of energy nutrients by cerebellar slices.
Neurochem Res. 2002 Mar;27(3):201-6. doi: 10.1023/a:1014828419900.
7
Lipogenesis in rat tissues following carbohydrate refeeding: spleen lipogenesis is modulated by insulin.
Mol Cell Biochem. 1997 Oct;175(1-2):149-52. doi: 10.1023/a:1006848015161.
8
Metabolic fuel utilization and pyruvate oxidation during the postnatal period.
J Inherit Metab Dis. 1996;19(4):432-42. doi: 10.1007/BF01799104.
9
Lipogenesis in the brain of suckling rats. Studies on the mechansim of mitochondrial-cytosolic carbon transfer.
Biochem J. 1980 Apr 15;188(1):163-8. doi: 10.1042/bj1880163.
10
The activities and intracellular distributions of enzymes of carbohydrate, lipid and ketone-body metabolism in lactating mammary glands from ruminants and non-ruminants.
Biochem J. 1981 Jun 15;196(3):747-56. doi: 10.1042/bj1960747.
本文引用的文献
1
Enzymes of fatty acid metabolism. IV. Preparation and properties of coenzyme A transferase.
J Biol Chem. 1956 Jul;221(1):15-31.
2
Brain metabolism during fasting.
J Clin Invest. 1967 Oct;46(10):1589-95. doi: 10.1172/JCI105650.
3
Acetyl transport mechanisms in the nervous system. The oxoglutarate shunt and fatty acid synthesis in the developing rat brain.
J Neurochem. 1968 Apr;15(4):315-23. doi: 10.1111/j.1471-4159.1968.tb11616.x.
4
Coenzyme A transferase activity in rat brain.
Biochem Biophys Res Commun. 1971 Apr 2;43(1):225-31. doi: 10.1016/s0006-291x(71)80111-0.
5
Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues.
Biochem J. 1971 Jan;121(1):41-7. doi: 10.1042/bj1210041.
6
A role of acetoacetyl-CoA synthetase in acetoacetate utilization by rat liver cell fractions.
Biochem Biophys Res Commun. 1971 Aug 20;44(4):1001-7. doi: 10.1016/0006-291x(71)90811-4.
7
Ketone-body utilization by adult and suckling rat brain in vivo.
Biochem J. 1971 Mar;122(1):13-8. doi: 10.1042/bj1220013.
8
Activities of enzymes of ketone-body utilization in brain and other tissues of suckling rats.
Biochem J. 1971 Jan;121(1):49-53. doi: 10.1042/bj1210049.
9
Removal and utilization of ketone bodies by the brain of newborn puppies.
J Neurochem. 1972 Sep;19(9):2169-73. doi: 10.1111/j.1471-4159.1972.tb05125.x.
10
CoA transferase in the brain and other mammalian tissues.
Arch Biochem Biophys. 1972 Feb;148(2):382-90. doi: 10.1016/0003-9861(72)90155-5.
Zotero 插件