乙酰乙酸与脑脂肪生成：大鼠脑可溶性部分中乙酰乙酰辅酶A合成酶的发育模式
Acetoacetate and brain lipogenesis: developmental pattern of acetoacetyl-coenzyme A synthetase in the soluble fraction of rat brain.
作者信息
Buckley B M, Williamson D H
出版信息
Biochem J. 1973 Mar;132(3):653-6. doi: 10.1042/bj1320653.
Abstract
The existence of acetoacetyl-CoA synthetase in rat brain cytosol is reported. The coupling of this enzyme with cytosolic acetoacetyl-CoA thiolase can provide acetyl-CoA for lipogenesis and cholesterol synthesis without the need for mitochondrial participation. This new route for acetoacetate utilization may be important in developing brain.
摘要
据报道，大鼠脑细胞溶胶中存在乙酰乙酰辅酶A合成酶。该酶与细胞溶胶中的乙酰乙酰辅酶A硫解酶偶联，可为脂肪生成和胆固醇合成提供乙酰辅酶A，而无需线粒体参与。这种新的乙酰乙酸利用途径在发育中的大脑中可能很重要。
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