Simpson E, Beverley P C
Clin Exp Immunol. 1973 Jul;14(3):443-55.
We have examined, by conventional histological methods, the immune response of normal and ALS-treated mice to a tumour xenograft. In normal mice the histology of the tumour site and lymphoid organs is in agreement with the hypothesis that rejection of tumour is by a cell-mediated response. In ALS-treated mice, lymphoid organs severely depleted of small lymphocytes, show many blast cells which may be responsible for cytotoxicity. After cessation of ALS there is still a striking lack of infiltrate at the tumour site suggestive of some form of `blocking' mechanism.
我们已通过传统组织学方法，研究了正常小鼠和经抗淋巴细胞血清（ALS）处理的小鼠对肿瘤异种移植的免疫反应。在正常小鼠中，肿瘤部位和淋巴器官的组织学与肿瘤排斥是由细胞介导的反应这一假设相符。在经ALS处理的小鼠中，严重缺乏小淋巴细胞的淋巴器官出现了许多可能具有细胞毒性的母细胞。在停止使用ALS后，肿瘤部位仍明显缺乏浸润，提示存在某种形式的“阻断”机制。
