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亚硝化单胞菌中氨氧化的特异性抑制剂。

Specific inhibitors of ammonia oxidation in Nitrosomonas.

作者信息

Hooper A B, Terry K R

出版信息

J Bacteriol. 1973 Aug;115(2):480-5. doi: 10.1128/jb.115.2.480-485.1973.

DOI:10.1128/jb.115.2.480-485.1973
PMID:4725614
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC246273/
Abstract

The following compounds or treatments have been shown to inhibit the oxidation of ammonia, but not the oxidation of hydroxylamine in cells of Nitrosomonas: (i) metal-binding agents such as allylthiourea or potassium cyanide; (ii) compounds such as SKF 525 which interact with cytochrome P-450 of mammalian microsomes; (iii) carbon monoxide; (iv) inhibitors of catalase, peroxidase, and amine oxidases such as thiosemicarbazide, ethylxanthate, and iproniazid, respectively; (v) uncouplers of oxidative phosphorylation such as m-chlorocarbonylcyanidephenylhydrazone; (vi) electron acceptors such as phenazine methosulfate; (vii) compounds such as methanol or N(2)O which react with free radicals; and (viii) illumination with 420 lux (5,000 foot candles) of light.

摘要

以下化合物或处理方法已被证明可抑制亚硝化单胞菌细胞中氨的氧化,但不能抑制羟胺的氧化:(i)金属结合剂,如烯丙基硫脲或氰化钾;(ii)与哺乳动物微粒体细胞色素P-450相互作用的化合物,如SKF 525;(iii)一氧化碳;(iv)过氧化氢酶、过氧化物酶和胺氧化酶的抑制剂,分别如氨基硫脲、乙基黄原酸盐和异烟肼;(v)氧化磷酸化解偶联剂,如间氯羰基氰基苯腙;(vi)电子受体,如吩嗪硫酸甲酯;(vii)与自由基反应的化合物,如甲醇或N₂O;以及(viii)用420勒克斯(5000英尺烛光)的光照。

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Specific inhibitors of ammonia oxidation in Nitrosomonas.亚硝化单胞菌中氨氧化的特异性抑制剂。
J Bacteriol. 1973 Aug;115(2):480-5. doi: 10.1128/jb.115.2.480-485.1973.
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本文引用的文献

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THE EFFECT OF 2-CHLORO, 6-(TRICHLOROMETHYL) PYRIDINE ON THE CHEMOAUTOTROPHIC METABOLISM OF NITRIFYING BACTERIA. I. AMMONIA AND HYDROXYLAMINE OXIDATION BY NITROSOMONAS.2-氯-6-(三氯甲基)吡啶对硝化细菌化学自养代谢的影响。I. 亚硝化单胞菌对氨和羟胺的氧化作用
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