与牛血清白蛋白或人血清白蛋白复合的脂多糖A的致热原性和免疫原性。
Pyrogenicity and immunogenicity of lipid A complexed with bovine serum albumin or human serum albumin.
作者信息
Rietschel E T, Kim Y B, Watson D W, Galanos C, Lüderitz O, Westphal O
出版信息
Infect Immun. 1973 Aug;8(2):173-7. doi: 10.1128/iai.8.2.173-177.1973.
Abstract
The lipid A component of bacterial lipopolysaccharides (endotoxins), when complexed to bovine serum albumin (BSA) or human serum albumin (HSA), was shown to be a potent pyrogen. Furthermore, rabbits could be protected against endotoxin fever by immunization with both lipid A.BSA and lipid A.HSA complexes. The results presented in this paper show that lipid A is responsible for the pyrogenic activity of endotoxins and their ability to induce pyrogenic immunity.
摘要
细菌脂多糖（内毒素）的脂质A成分，当与牛血清白蛋白（BSA）或人血清白蛋白（HSA）复合时，被证明是一种强效热原。此外，用脂质A.BSA和脂质A.HSA复合物免疫兔子可以预防内毒素发热。本文给出的结果表明，脂质A对内毒素的致热活性及其诱导热原免疫的能力负责。
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本文引用的文献
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MODIFICATION OF HOST RESPONSES TO BACTERIAL ENDOTOXINS. II. PASSIVE TRANSFER OF IMMUNIY TO BACTERIAL ENDOTOXIN WITH FRACTIONS CONTAINING 19S ANTIBODIES.宿主对细菌内毒素反应的改变。II. 用含19S抗体的组分被动转移对细菌内毒素的免疫力。
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