Root R K, Wolff S M
J Exp Med. 1968 Aug 1;128(2):309-23. doi: 10.1084/jem.128.2.309.
When rabbits sensitized to human serum albumin (HSA) are challenged intravenously with specific antigen, fever develops and two transferable pyrogens can be demonstrated in the circulation. The first appears prior to the development of fever and has properties consistent with soluble antigen-antibody complexes. These have been shown to be pyrogenic when prepared in vitro and to produce a state of febrile tolerance when repeatedly administered. The second pyrogen, demonstrable during fever in donor rabbits, appears to be similar to endogenous pyrogen described in other experimental fevers. It is postulated that the formation of antigen-antibody complexes constitutes an important initial phase of the febrile reaction in this type of immune fever.
当对人血清白蛋白（HSA）致敏的兔子静脉注射特定抗原进行激发时，会出现发热，并且在循环中可检测到两种可转移的致热原。第一种致热原在发热出现之前就已出现，其特性与可溶性抗原 - 抗体复合物一致。体外制备时，这些复合物已被证明具有致热性，并且反复给药会产生发热耐受状态。第二种致热原在供体兔子发热期间可检测到，似乎与其他实验性发热中描述的内源性致热原相似。据推测，在这种免疫性发热中，抗原 - 抗体复合物的形成构成了发热反应的一个重要初始阶段。
