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Synthetic antidiarrheal agents. 2,2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides.

作者信息

Stokbroekx R A, Vandenberk J, Van Heertum A H, Van Laar G M, Van der Aa M J, Van Bever W F, Janssen P A

出版信息

J Med Chem. 1973 Jul;16(7):782-6. doi: 10.1021/jm00265a009.

DOI:10.1021/jm00265a009
PMID:4725924
Abstract
摘要

相似文献

1
Synthetic antidiarrheal agents. 2,2-Diphenyl-4-(4'-aryl-4'-hydroxypiperidino)butyramides.合成止泻剂。2,2-二苯基-4-(4'-芳基-4'-羟基哌啶基)丁酰胺。
J Med Chem. 1973 Jul;16(7):782-6. doi: 10.1021/jm00265a009.
2
Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 2. Difneozine, a potent, orally active and safe antidiarrheal agent in rats.地芬诺辛(R 15403),是地芬诺酯(R 1132)的活性代谢产物。2. 地芬诺辛,一种对大鼠强效、口服活性且安全的止泻剂。
Arzneimittelforschung. 1972 Mar;22(3):516-8.
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Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 7: Clinical investigation. Efficacy and safety of loperamide in patients with severe chronic diarrhea.洛哌丁胺(R 18 553),一种新型止泻药。第7部分:临床研究。洛哌丁胺治疗严重慢性腹泻患者的疗效和安全性。
Arzneimittelforschung. 1974 Oct;24(10):1657-60.
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Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine.洛哌丁胺(R 18 553),一种新型止泻药。第1部分:体内口服药理学及急性毒性。与吗啡、可待因、地芬诺酯和地芬诺辛的比较。
Arzneimittelforschung. 1974 Oct;24(10):1633-6.
5
Loperamide, diphenoxylate, and codeine phosphate in chronic diarrhoea.洛哌丁胺、地芬诺酯及磷酸可待因治疗慢性腹泻
Br Med J. 1980 Feb 23;280(6213):524. doi: 10.1136/bmj.280.6213.524.
6
Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 8: Clinical investigation. Use of a flexible dosage schedule in a double-blind comparison of loperamide with diphenoxylate in 614 patients suffering from acute diarrhea.洛哌丁胺(R 18 553),一种新型止泻药。第八部分:临床研究。在614例急性腹泻患者中,采用灵活剂量方案对洛哌丁胺与地芬诺酯进行双盲比较。
Arzneimittelforschung. 1974 Oct;24(10):1660-5.
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Symptomatic therapy for chronic diarrhoea. A comparison of the effects of codeine phosphate and diphenoxylate hydrochloride.慢性腹泻的对症治疗。磷酸可待因与盐酸地芬诺酯疗效比较。
Med J Aust. 1973 Apr 28;1(17):842-3. doi: 10.5694/j.1326-5377.1973.tb110731.x.
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Evaluation of a new anti-diarrhoeal drug (Lomotil).
Indian Pediatr. 1970 Feb;7(2):127-30.
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Warning: the use of lomotil in children.
Pediatrics. 1973 Jan;51(1):132-4.
10
Double-blind cross-over study comparing loperamide, codeine and diphenoxylate in the treatment of chronic diarrhea.比较洛哌丁胺、可待因和地芬诺酯治疗慢性腹泻的双盲交叉研究。
Gastroenterology. 1980 Dec;79(6):1272-5.

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Loperamide, an antidiarrheal agent, induces apoptosis and DNA damage in leukemia cells.
洛哌丁胺是一种止泻药,可诱导白血病细胞凋亡和DNA损伤。
Oncol Lett. 2018 Jan;15(1):765-774. doi: 10.3892/ol.2017.7435. Epub 2017 Nov 17.
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Metabolomics approach to serum biomarker for loperamide-induced constipation in SD rats.代谢组学方法研究洛哌丁胺诱导的SD大鼠便秘的血清生物标志物
Lab Anim Res. 2014 Mar;30(1):35-43. doi: 10.5625/lar.2014.30.1.35. Epub 2014 Mar 24.
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Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.[N-甲基-11C]N-去甲基洛哌丁胺作为一种用于成像P-糖蛋白功能的新型改良PET放射性示踪剂的合成与评价。
J Med Chem. 2008 Oct 9;51(19):6034-43. doi: 10.1021/jm800510m. Epub 2008 Sep 11.
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Difenoxin and loperamide: studies on possible mechanisms of intestinal antisecretory action.地芬诺辛与洛哌丁胺:肠道抗分泌作用可能机制的研究
Naunyn Schmiedebergs Arch Pharmacol. 1993 Feb;347(2):231-7. doi: 10.1007/BF00169273.
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Pathogenesis and pharmacology of diarrhea.腹泻的发病机制与药理学
Vet Res Commun. 1986 Sep;10(5):355-97. doi: 10.1007/BF02214001.
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Effect of loperamide, haloperidol and methadone in rats trained to discriminate morphine from saline.洛哌丁胺、氟哌啶醇和美沙酮对训练区分吗啡和生理盐水的大鼠的影响。
Psychopharmacologia. 1975;41(3):267-70. doi: 10.1007/BF00428935.
9
Disposition and metabolism of [14C]loperamide in rats.[14C]洛哌丁胺在大鼠体内的处置与代谢
Eur J Drug Metab Pharmacokinet. 1979;4(4):199-206. doi: 10.1007/BF03189427.
10
Double-blind placebo-controlled study of loperamide (Imodium) in chronic diarrhoea caused by ileocolic disease or resection.洛哌丁胺(易蒙停)治疗回结肠疾病或切除术后所致慢性腹泻的双盲安慰剂对照研究
Gut. 1977 Jul;18(7):575-9. doi: 10.1136/gut.18.7.575.