Morra L, Ponassi A, Gigli G, Vercelli M, Sacchetti C
Scand J Haematol. 1979 Apr 4;22(4):311-6. doi: 10.1111/j.1600-0609.1979.tb00425.x.
The incidence of circulating colony-forming cells (CFU-C) and the ability of peripheral leucocytes to stimulate the colony formation (CSA) have been studied through a double layer agar culture system in 26 patients with neutrophilic leucocytosis and compared to the values obtained in 26 normal subjects. Both mean CFU-C incidence and mean leucocyte CSA of the whole group of patients were found significantly higher than normal, but considerable variation was observed among singular patients. The different patterns of blood CFU-C and leucocyte CSA are discussed. The combined evaluation of blood CFU-C and leucocyte CSA is found a useful tool to investigate the pathogenetic mechanisms of neutrophilic leucocytosis.
通过双层琼脂培养系统，对26例中性粒细胞增多症患者循环集落形成细胞（CFU-C）的发生率和外周白细胞刺激集落形成的能力（CSA）进行了研究，并与26例正常受试者所得值进行比较。发现患者全组的平均CFU-C发生率和平均白细胞CSA均显著高于正常，但个体患者之间存在相当大的差异。讨论了血液CFU-C和白细胞CSA的不同模式。发现血液CFU-C和白细胞CSA的联合评估是研究中性粒细胞增多症发病机制的有用工具。
