• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Bilirubin as a cholestatic agent. II. Effect of variable doses of bilirubin on the severity of manganese-bilirubin cholestasis.胆红素作为一种胆汁淤积剂。II. 不同剂量胆红素对锰-胆红素性胆汁淤积严重程度的影响。
Am J Pathol. 1973 Sep;72(3):427-32.
2
Bilirubin as a cholestatic agent. III. Prevention of bilirubin-related cholestasis by sulfobromophthalein.胆红素作为一种胆汁淤积剂。III. 用磺溴酞钠预防胆红素相关的胆汁淤积
Arch Pathol. 1975 Sep;99(9):492-5.
3
Bilirubin as a cholestatic agent. IV. Effect of bilirubin and sulfobromophthalein (BSP) on biliary manganese excretion.胆红素作为一种胆汁淤积剂。IV. 胆红素和磺溴酞钠（BSP）对胆汁锰排泄的影响。
Arch Pathol. 1975 Sep;99(9):496-8.
4
Biliary excretion in Sprague-Dawley and Gunn rats during manganese-bilirubin-induced cholestasis.锰-胆红素诱导胆汁淤积期间，斯普拉格-道利大鼠和冈恩大鼠的胆汁排泄情况。
Hepatology. 1988 Sep-Oct;8(5):1069-78. doi: 10.1002/hep.1840080515.
5
Bilirubin excretion pattern in manganese-bilirubin cholestasis.
Arch Int Pharmacodyn Ther. 1979 May;239(1):24-35.
6
Physiologic and morphologic natural history of a model of intrahepatic cholestasis (manganese-bilirubin overload).肝内胆汁淤积模型（锰 - 胆红素过载）的生理和形态学自然史。
Am J Pathol. 1972 Mar;66(3):577-88.
7
Hepatic subcellular distribution of manganese in manganese and manganese-bilirubin induced cholestasis.锰及锰-胆红素诱导的胆汁淤积中锰的肝脏亚细胞分布
Biochem Pharmacol. 1985 Nov 1;34(21):3857-65. doi: 10.1016/0006-2952(85)90435-6.
8
Methyl isobutyl ketone metabolites and potentiation of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.
Toxicol Appl Pharmacol. 1988 Mar 15;92(3):419-27. doi: 10.1016/0041-008x(88)90181-0.
9
Potentiation by methyl isobutyl ketone of the cholestasis induced in rats by a manganese-bilirubin combination or manganese alone.
Toxicol Appl Pharmacol. 1987 Dec;91(3):477-83. doi: 10.1016/0041-008x(87)90069-x.
10
Bilirubin as a cholestatic agent. Physiologic and morphologic observations.
Am J Pathol. 1971 Feb;62(2):181-94.

本文引用的文献

1
THE ESTIMATION OF BILIRUBIN IN LIVER.肝脏中胆红素的测定
Clin Chim Acta. 1965 Mar;11:278-80. doi: 10.1016/0009-8981(65)90075-6.
2
Alteration of the plasma disappearance and biliary excretion patterns of exogenously administered bilirubin by alpha-nephthylisothiocyanate.
J Pharmacol Exp Ther. 1967 Feb;115(2):330-6.
3
Bilirubin as a cholestatic agent. Physiologic and morphologic observations.
Am J Pathol. 1971 Feb;62(2):181-94.
4
Physiologic and morphologic natural history of a model of intrahepatic cholestasis (manganese-bilirubin overload).肝内胆汁淤积模型（锰 - 胆红素过载）的生理和形态学自然史。
Am J Pathol. 1972 Mar;66(3):577-88.

胆红素作为一种胆汁淤积剂。II. 不同剂量胆红素对锰-胆红素性胆汁淤积严重程度的影响。

Bilirubin as a cholestatic agent. II. Effect of variable doses of bilirubin on the severity of manganese-bilirubin cholestasis.

作者信息

Boyce W, Witzleben C L

出版信息

Am J Pathol. 1973 Sep;72(3):427-32.

PMID:4728892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1904029/
Abstract

These experiments demonstrate that the cholestasis following manganese-bilirubin administration varies directly in severity in relation to the amount of bilirubin administered. This suggests that the cholestasis is related to critical bilirubin accumulation in some compartment of the biliary excretory pathway. However, in the immediate precholestatic period, the levels of bilirubin in all three compartments of blood, liver and bile also vary in direct relation to the amount of bilirubin administered. The critical site of bilirubin accumulation or concentration is not, therefore, defined by these experiments.

摘要

这些实验表明，给予锰-胆红素后发生的胆汁淤积，其严重程度与所给予的胆红素量直接相关。这表明胆汁淤积与胆汁排泄途径某些部位的关键胆红素蓄积有关。然而，在胆汁淤积前期，血液、肝脏和胆汁这三个部位的胆红素水平也都与所给予的胆红素量直接相关。因此，这些实验并未确定胆红素蓄积或浓缩的关键部位。