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大剂量25-羟胆钙化醇对无肾大鼠的钙动员作用。

Calcium-mobilizing effect of large doses of 25-hydroxycholecalciferol in anephric rats.

作者信息

Pavlovitch H, Garabedian M, Balsan S

出版信息

J Clin Invest. 1973 Oct;52(10):2656-9. doi: 10.1172/JCI107458.

DOI:10.1172/JCI107458

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC302526/

Abstract

The effect of high doses of 25-hydroxycholecalciferol on plasma calcium concentration was studied in rats receiving a low-calcium normal vitamin D diet. In bilaterally nephrectomized animals, as in sham-operated controls, 62.5 nmol of 25-hyroxycholecalciferol did not produce a rise of plasma calcium concentration. In contrast, the administration of 125 or 625 nmol, doses 1,000-5,000 times the minimal active dose in D-deficient rats, was followed in both groups of animals by a significant increase of plasma calcium concentration. Removal of either parathyroids alone or parathyroid and thyroid glands did not suppress this effect. These data suggest that when large doses are used in vivo, the renal conversion of 25-hydroxycholecalciferol to more polar metabolites is not an obligatory step for its calcium-mobilizing action. The present study does not elucidate, however, the exact mechanism(s) of this effect.

摘要

在给予低钙正常维生素D饮食的大鼠中，研究了高剂量25-羟胆钙化醇对血浆钙浓度的影响。在双侧肾切除的动物中，与假手术对照组一样，62.5 nmol的25-羟胆钙化醇并未使血浆钙浓度升高。相比之下，给予125或625 nmol（这两个剂量是维生素D缺乏大鼠最小活性剂量的1000 - 5000倍）后，两组动物的血浆钙浓度均显著升高。单独切除甲状旁腺或同时切除甲状旁腺和甲状腺并不能抑制这种作用。这些数据表明，当在体内使用大剂量时，25-羟胆钙化醇向极性更强的代谢产物的肾脏转化对于其钙动员作用而言并非必需步骤。然而，本研究并未阐明这种作用的确切机制。