25-羟胆钙化醇向1,25-二羟胆钙化醇肾转化的激素调控。
Hormonal control of the renal conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol.
作者信息
Rasmussen H, Wong M, Bikle D, Goodman D B
出版信息
J Clin Invest. 1972 Sep;51(9):2502-4. doi: 10.1172/JCI107065.
Abstract
Isolated renal tubules from vitamin D-deficient chicks catalyse the in vitro conversion of 25-hydroxycholecalciferol to 1,25-dihydroxycholecalciferol. This conversion is stimulated by 5 x 10(-10) M bovine parathyroid hormone, or by 10(-6) M cyclic AMP. It is inhibited by 10(-9) M porcine calcitonin. It is concluded that these hormonal controls of the synthesis of the renal hormone 1,25-dihydroxycholecalciferol are of particular physiological significance in coordinating the activities of the various organs involved in extracellular calcium homeostasis.
摘要
来自维生素 D 缺乏雏鸡的分离肾小管可在体外催化 25 - 羟胆钙化醇转化为 1,25 - 二羟胆钙化醇。这种转化受到 5×10⁻¹⁰ M 牛甲状旁腺激素或 10⁻⁶ M 环磷酸腺苷的刺激。它受到 10⁻⁹ M 猪降钙素的抑制。得出的结论是，这些对肾激素 1,25 - 二羟胆钙化醇合成的激素调控在协调参与细胞外钙稳态的各个器官的活动方面具有特殊的生理意义。
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