Chernoff N, Rogers E, Carver B, Kavlock R, Gray E
Teratology. 1979 Apr;19(2):165-9. doi: 10.1002/tera.1420190206.
Mice (CD-1 strain) were placed on diets containing either municipal drinking water (Durham, North Carolina) or water that had been distilled and passed through cartridges to reduce organics and remove inorganics. After a two-week acclimation period, animals were bred and pregnancy confirmed by the presence of a sperm plug. During the 8-month course of the study, approximately 500 pregnant mice were sacrificed on day 18 of gestation and their fetuses examined for visceral and skeletal anomalies. No significant water-related effects were found on any fetal parameter studied except for a 28.1% incidence of supernumerary ribs in the tap-water group as compared to 21.1% in the purified-water group. No differences were noted in the type or occurrence of anomalies between the two groups. A month to month variation was observed in a number of parameters. The degree of variation was similar for the treatment groups, suggesting that these changes might be random fluctuations.
将CD - 1品系的小鼠置于含有市政饮用水（北卡罗来纳州达勒姆）或经过蒸馏并通过滤筒以减少有机物和去除无机物的水的饮食中。经过两周的适应期后，让动物繁殖，并通过有精子栓确认怀孕。在为期8个月的研究过程中，大约500只怀孕小鼠在妊娠第18天被处死，并检查其胎儿的内脏和骨骼异常情况。除了自来水中超数肋骨的发生率为28.1%，而纯净水组为21.1%外，在所研究的任何胎儿参数上均未发现与水相关的显著影响。两组之间在异常的类型或发生率方面没有差异。在一些参数上观察到逐月变化。各治疗组的变化程度相似，这表明这些变化可能是随机波动。
