Staples R E, Worthy W C, Marks T A
Teratology. 1979 Apr;19(2):237-43. doi: 10.1002/tera.1420190214.
Pregnant CD-1 mice drank either chlorinated tap water obtained at NIEHS from the City of Durham, North Carolina municipal water supply or this same water passed in sequence through an organic removal cartridge and a demineralizer, followed by glass distillation. No significant overall differences in the reproductive status of pregnant mice were noted when the two groups were compared. Similarly, no significant overall influence on the incidence of malformed fetuses could be traced to the purity of drinking water. Month by month comparisons indicated that there were three statistically significant differences; all of which indicated improved performance for the mice that drank tap water. When the results for both groups were combined and a month by month comparison was made there was a significant difference in the pregnancy rate for February (68%) as compared with an overall pregnancy rate of 80% and a 79-93% spread for the other months, but the decrease was due to the low incidence of pregnancy in the group that drank the purified water.
怀孕的CD - 1小鼠饮用的水，要么是从北卡罗来纳州达勒姆市市政供水系统获取的、经美国国立环境卫生科学研究所（NIEHS）氯化处理的自来水，要么是同样的水依次通过一个有机物质去除滤筒和一个去离子器，然后进行玻璃蒸馏得到的水。比较这两组时，未发现怀孕小鼠的生殖状况存在显著的总体差异。同样，未发现饮用水纯度对畸形胎儿的发生率有显著的总体影响。逐月比较表明存在三个具有统计学意义的差异；所有这些差异都表明饮用自来水的小鼠表现更好。当将两组结果合并并逐月比较时，2月份的怀孕率（68%）与总体怀孕率80%以及其他月份79% - 93%的范围相比存在显著差异，但这种下降是由于饮用纯净水的组怀孕发生率较低所致。
