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豚鼠对结构不相关抗原致敏的遗传控制及其与组织相容性抗原的关系。

Genetic control of sensitization to structurally unrelated antigens and its relationship to histocompatibility antigens in guinea-pigs.

作者信息

Greczy A F, de Weck A L

出版信息

Immunology. 1975 Feb;28(2):331-42.

PMID:47308
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445802/
Abstract

Five strains of guinea-pigs homozygous for GPL-A and 2/13 histocompatibility antigens were sequentially immunized with seven structurally unrelated antigens (TGAL, BPO-BGG, ASAN, BPO-PLL, phenetidine, horseradish peroxidase and DNP-dodecapeptide). Considerable differences in the immune response were observed, as measured by delayed skin reactivity and antigen-induced lymphocyte stimulation in vitro. The data presented show that when the progeny of various back-cross matings are analysed for their responder status, the responses to the antigens (TGAL, BPO-BGG, phenetidine and ASAN) are in most cases linked to the genes controlling the respective histocompatibility antigens. However, it appears that the responses to the various antigens in our system may be under polygenic control.

摘要

五只对GPL - A和2/13组织相容性抗原纯合的豚鼠品系，依次用七种结构不相关的抗原（TGAL、BPO - BGG、ASAN、BPO - PLL、苯乙啶、辣根过氧化物酶和DNP - 十二肽）进行免疫。通过迟发性皮肤反应性和体外抗原诱导的淋巴细胞刺激来衡量，观察到免疫反应存在相当大的差异。所呈现的数据表明，当分析各种回交后代的反应状态时，对这些抗原（TGAL、BPO - BGG、苯乙啶和ASAN）的反应在大多数情况下与控制各自组织相容性抗原的基因相关联。然而，在我们的系统中，对各种抗原的反应似乎可能受多基因控制。

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本文引用的文献

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STUDIES ON ARTIFICIAL ANTIGENS. III. THE GENETIC CONTROL OF THE IMMUNE RESPONSE TO HAPTEN-POLY-L-LYSINE CONJUGATES IN GUINEA PIGS.人工抗原的研究。III. 豚鼠对半抗原-聚-L-赖氨酸缀合物免疫反应的遗传控制。
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The immune response to a hybrid protein molecule; specificity of secondary stimulation and of tolerance induction.对杂合蛋白分子的免疫反应；二次刺激和耐受性诱导的特异性。
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Differences in immune response to synthetic antigens in two inbred strains of guinea-pigs.两种近交系豚鼠对合成抗原免疫反应的差异。
Immunology. 1967 May;12(5):573-81.
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J Exp Med. 1965 Sep 1;122(3):517-31. doi: 10.1084/jem.122.3.517.
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Studies on synthetic polypeptide antigens. XX. Genetic control of the antibody response in the rat to structurally different synthetic polypeptide antigens.合成多肽抗原的研究。二十。大鼠对结构不同的合成多肽抗原抗体反应的遗传控制。
J Immunol. 1968 Oct;101(4):730-42.
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The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs.豚鼠对无机金属化合物接触致敏的遗传控制。
Immunology. 1968 May;14(5):707-11.
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