两种近交系豚鼠对合成抗原免疫反应的差异。
Differences in immune response to synthetic antigens in two inbred strains of guinea-pigs.
作者信息
Ben-Efraim S, Fuchs S, Sela M
出版信息
Immunology. 1967 May;12(5):573-81.
The study of the immunogenicity of some linear and multichain synthetic polypetides in guinea-pigs, of inbred strains 2 and 13 led to their division into three categories: (a) immunogenic in both inbred strains: linear copolymer of tyrosine, glutamic acid and alanine; (b) immunogenic in strain 13 and negative in strain 2: linear copolymer of tyrosine and glutamic acid; and (c) immunogenic in strain 2 and negative in strain 13: linear and branched copolymers containing lysine. No immune response was detected in strain 2 guinea-pigs to the copolymer of tyrosine, glutamic acid and lysine, composed only of the D-optical isomers. The immune response, or lack of response, in F hybrids of the inbred strains was identical with that of inbred strain 2 suggesting that the genetic determinants of this strain are dominant. No cross-reactions were observed at the delayed stage in inbred strain 2 between linear and multichain copolymers of similar composition.
对豚鼠近交系2和13中一些线性和多链合成多肽免疫原性的研究，导致它们被分为三类：(a) 在两个近交系中均具有免疫原性：酪氨酸、谷氨酸和丙氨酸的线性共聚物；(b) 在13系中具有免疫原性而在2系中呈阴性：酪氨酸和谷氨酸的线性共聚物；以及(c) 在2系中具有免疫原性而在13系中呈阴性：含赖氨酸的线性和支链共聚物。在2系豚鼠中未检测到对仅由D-旋光异构体组成的酪氨酸、谷氨酸和赖氨酸共聚物的免疫反应。近交系F杂种中的免疫反应或无反应与近交系2相同，表明该品系的遗传决定因素具有显性。在近交系2中，在延迟阶段未观察到组成相似的线性和多链共聚物之间的交叉反应。
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