豚鼠的组织相容性抗原与免疫应答的遗传控制IV. 自身抗独特型抗体对淋巴细胞增殖的特异性抑制
Histocompatibility antigens and genetic control of the immune response in guinea pigs IV. Specific inhibition of lymphocyte proliferation by auto-anti-idiotypic antibodies.
作者信息
Geczy A F
出版信息
J Exp Med. 1977 Apr 1;145(4):1093-8. doi: 10.1084/jem.145.4.1093.
Abstract
The in vitro T-cell proliferation induced by penicilloylated bovine IgG (BPO-BGG) in sensitized strain 2 guinea pigs could be specifically blocked by the serum of guinea pig (*305) which had been repeatedly immunized with BPO-BGG over a period of 9 mo. The antibodies which appeared in the serum of this animal (*305) were functionally similar to the strain 2 anti-idiotypic antibodies (a strain 2 BPO-BGG) raised by immunizing strain 2 guinea pigs with immuno-adsorbent column-purified BPO-BGG. Animal *305 had no detectable antibodies to BPO-BGG and failed to give a delayed hypersensitivity skin response when challenged with BPO-BGG.
摘要
青霉素酰化牛IgG（BPO - BGG）诱导的致敏2系豚鼠体外T细胞增殖，可被豚鼠（* 305）的血清特异性阻断，该豚鼠在9个月的时间里反复用BPO - BGG免疫。该动物（* 305）血清中出现的抗体在功能上类似于用免疫吸附柱纯化的BPO - BGG免疫2系豚鼠产生的2系抗独特型抗体（2系BPO - BGG）。动物* 305没有可检测到的针对BPO - BGG的抗体，在用BPO - BGG攻击时也未出现迟发型超敏皮肤反应。
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本文引用的文献
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