铬诱导的大鼠高血糖症。

Chromium-induced hyperglycemia in the rat.

作者信息

Ghafghazi T, Maghbareh A, Barnett R

出版信息

Toxicology. 1979 Jan;12(1):47-52. doi: 10.1016/0300-483x(79)90031-3.

Abstract

The acute administration of chromium chloride (Cr) produces hyperglycemia in rats. Adrenalectomy prevents the hyperglycemic effect but not the glucose intolerance. Subacute exposure of rats to Cr for 7--23 days does not change the resting blood glucose nor is there an acute or subacute effect on tolerance to glucose load. Administration of Cr does not influence acute insulin hypoglycemia. Thus contrary to Cr deficient animal, at the concentrations tested, Cr appears to be a hyperglycmiec agent to rats with minimal subacute effects.

摘要

给大鼠急性注射氯化铬（Cr）会使其出现高血糖。肾上腺切除术可预防高血糖效应，但不能预防葡萄糖不耐受。大鼠亚急性暴露于Cr 7至23天不会改变静息血糖，对葡萄糖负荷耐受性也无急性或亚急性影响。注射Cr不影响急性胰岛素低血糖。因此，与缺铬动物相反，在所测试的浓度下，Cr对大鼠似乎是一种高血糖剂，亚急性影响极小。