呼肠孤病毒：非感染性病毒成分对细胞脱氧核糖核酸合成的影响
Reovirus: effect of noninfective viral components on cellular deoxyribonucleic acid synthesis.
作者信息
Hand R, Tamm I
出版信息
J Virol. 1973 Feb;11(2):223-31. doi: 10.1128/JVI.11.2.223-231.1973.
Abstract
We determined the effects of noninfective reovirus components on cellular deoxyribonucleic acid (DNA) synthesis. Reovirus inactivated by ultraviolet light inhibited cellular DNA synthesis, whereas reovirus cores and empty capsids did not. Both cores and empty capsids were adsorbed to cells. Adenine-rich ribonucleic acid (RNA) from reovirus, adsorbed to cells in the presence of diethyl-aminoethyl-dextran, produced a partial inhibition of DNA synthesis. RNA was synthesized in the presence of actinomycin D after infection with ultraviolet light-irradiated reovirus, and this RNA synthesis was not due to multiplicity reactivation of virus infectivity. These data suggest that viral structural proteins do not inhibit DNA synthesis and that the inhibition produced by ultraviolet-irradiated virus may be mediated in part or in toto by a newly synthesized viral product.
摘要
我们确定了非感染性呼肠孤病毒成分对细胞脱氧核糖核酸（DNA）合成的影响。经紫外线灭活的呼肠孤病毒抑制细胞DNA合成，而呼肠孤病毒核心颗粒和空衣壳则无此作用。核心颗粒和空衣壳均可吸附至细胞。在二乙氨基乙基葡聚糖存在的情况下，吸附于细胞的呼肠孤病毒富含腺嘌呤的核糖核酸（RNA）可部分抑制DNA合成。在用紫外线照射的呼肠孤病毒感染后，在放线菌素D存在的情况下可合成RNA，且这种RNA合成并非由于病毒感染性的多重复活所致。这些数据表明，病毒结构蛋白不抑制DNA合成，紫外线照射病毒所产生的抑制作用可能部分或全部由新合成的病毒产物介导。
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Growth characteristics of reovirus type 2: ultraviolet light inactivated virion preparations and cell death.呼肠孤病毒2型的生长特性：紫外线灭活病毒粒子制剂与细胞死亡
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