Nonoyama M, Graham A F
J Virol. 1970 Nov;6(5):693-4. doi: 10.1128/JVI.6.5.693-694.1970.
Virus obtained from five plaques of reovirus was serially passaged in L cells. Defective virions arose in each clone by the seventh passage. Such defective virions lacked the largest of the 10 segments of the double-stranded ribonucleic acid genome.
从五个呼肠孤病毒噬菌斑中获得的病毒在L细胞中连续传代。到第七代时,每个克隆中都出现了缺陷病毒颗粒。这种缺陷病毒颗粒缺乏双链核糖核酸基因组10个片段中最大的那个片段。