IgM和IgG1抗半抗原抗体的单克隆产生。
Monoclonal production of both IgM and IgG1 antihapten antibody.
作者信息
Press J L, Klinman N R
出版信息
J Exp Med. 1973 Jul 1;138(1):300-5. doi: 10.1084/jem.138.1.300.
Abstract
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse micro-chain antibody and goat antimouse gamma1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by the clonal progeny of a single precursor cell.
摘要
通过放射免疫分析法，使用碘化的纯化山羊抗小鼠μ链抗体和山羊抗小鼠γ1链抗体，对初级和次级脾灶产生的抗二硝基苯酚（DNP）抗体的重链类别进行了分析。产生IgM和IgG1抗DNP抗体的初级和次级脾灶的频率（分别为16%和14%）明显高于随机分布所预测的频率。因此，似乎IgM和IgG1抗体可由单个前体细胞的克隆后代产生。
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J Immunol. 1972 Jun;108(6):1712-7.
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